Big design-build infrastructure projects often turn out to be money-losers for design-build contractors, preventing contractors from covering their overhead, much less earning a profit, according to a ...

Recent decades have seen ever louder calls for improved study design and reproducibility standards in animal research. This stems from wider discussions across the scientific community about the ...

Good experiments start with good planning. The analysis of genetic and molecular information involves increasingly sophisticated tools and methodologies, many of which are advancing at a fast pace.

Developing treatments for rare diseases poses many unique challenges that cannot be addressed by traditional study designs. Small populations will result in prolonged enrolment periods and/or ...

Once you have determined your research question, the next step is to decide on a research design. As random assignment tends to be challenging in SoTL, most projects tend to fall into the ...

Noninferiority clinical trials have become a major tool for the evaluation of drugs, devices, biologics, and other medical treatments. Treatment with placebo or with a no-treatment control in a study ...