Mutations in 3 genes (SPG4, SPG3, and SPG31) are implicated in one half of the autosomal dominant hereditary spastic paraplegias, which are part of the larger group of hereditary spastic diplegias ...

Researchers from the University of Seville and the Seville Institute of Biomedicine (IBiS), in collaboration with the University of Cambridge, have identified a new role for one of the genes related ...

Autosomal recessive ulcero-mutilating neuropathy with spastic paraplegia is a very rare disease since only few cases were described up to date. We report in this study a consanguineous Moroccan family ...

Spastic paraplegia (SP) in hereditary form is a genetically and clinically heterogeneous group of diseases with distinctive features of axonal degeneration in corticospinal tracts. Progressive ...

A study by Rice University biochemists has revealed specific defects in nerve cells that arise from two genetic defects known to cause hereditary spastic paraplegia (HSP). The research, which is ...

Rare diseases, as the name indicates, only affect a small part of the population. However, for those affected they are particularly challenging, often especially because research into such rare ...

Hereditary spastic paraplegia (HSP), also known as familial spastic paraparesis, is a term used for a group of inherited diseases that affect the upper motor neurons traveling from the brain through ...

New research is yielding clues about hereditary spastic paraplegia (HSP), a group of inherited neurological disorders that affect about 20,000 people in the United States. A new study offers the first ...

Two little girls from different parts of the globe who share an extremely rare and debilitating genetic brain disorder have been united by Queensland research aiming to find a breakthrough drug ...

Newark, New Castle, USA, April 13, 2023 (GLOBE NEWSWIRE) -- The global hereditary spastic paraplegia market is projected to register a revenue CAGR of 6.70%, according to the latest evaluation by ...

Biologists have identified gene mutations that cause hereditary spastic paraplegia (HSP), a group of inherited disorders that cause progressive weakness and stiffness of the leg muscles. The discovery ...