Announcing a new publication for Acta Materia Medica journal. In addition to regulating lipid biosynthesis and uptake, sterol regulatory element binding protein (SREBP) is involved in mediating ...

Mevalonate (MVA) pathway metabolites are essential for cancer cell survival and growth. Expression of the genes encoding MVA pathway enzymes is controlled by the sterol regulatory element-binding ...

Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid ...

Medific Inc. has described substituted thiazolidinedione derivatives acting as sterol regulatory element binding protein (SREBP; SREBF1) inhibitors reported to be useful for the treatment of cancer, ...

BUFFALO, N.Y. — Research suggests one of the many ways cancer can spread is an explosive form of cell death known as necroptosis. This regulated self-destruction purges cancerous and other diseased ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 40 (October 2, 2012), pp. 15974-15975 (2 pages) ...

Scientists have uncovered new information about the mechanism by which brain cells die following a stroke, as well as a possible way to mitigate that damage. Scientists at the Brain Research Centre, a ...

Macronutrients (carbohydrate, lipids, and protein) play a fundamental role in mammalian growth and development by serving as a source of energy as well as components for the synthesis of structural ...

Tsukuba, Japan—Researchers have been studying the transcription factor SREBP, a critical regulator of lipid biosynthesis. Precursor SREBP proteins, located in the endoplasmic reticulum (ER) of the ...