Artios Announces First Patient Dosed in Randomized Phase 2 POLKA Study Evaluating DNA Polymerase Theta Inhibitor ART6043 in gBRCA-mutated HER2-Negative Breast Cancer

Key milestone positions ART6043 as the most advanced Pol-theta inhibitor in clinical development; the potentially first-in-class program is ...

DNA repair protein gene gone rogue may unlock new cancer treatments

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

Researchers identify enzyme that prevents chromosome breaks during DNA copying

Researchers at The University of Texas Medical Branch (UTMB) have identified how a key enzyme called ATR protects DNA from ...
Phys.org

Licensed to live: DNA's replication mechanisms compiled in study

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Overactive MYC helps tumors fix DNA breaks and resist chemotherapy, study finds

A protein best known for driving cancer growth also helps damaged tumor cells survive by repairing their DNA, according to a ...
eLife

Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide ...
Tech Times

Wisconsin Researchers Map Bacterial DNA Repair Restart, Revealing New Antibiotic Targets

Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that le ...