Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the brain—regulate neuroinflammation and promote the development of behaviors ...

Neuroinflammation, a prolonged activation of the brain's immune system prompted by infections or other factors, has been linked to the disruption of normal mental functions. Past studies, for instance ...

For millions of people living with the long-term effects of traumatic brain injury (TBI), the prevailing belief has been that ...

Chronic pain management constitutes a considerable unmet medical challenge. Existing treatments for chronic pain are either ineffective or result in undesirable side effects such as development of ...

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system. Microglia, the primary immune cells of the central ...

A new review uncovers how chronic alcohol consumption accelerates Alzheimer’s pathology through oxidative stress and neuroinflammatory cascades, while spotlighting promising molecular and metabolic ...

Please provide your email address to receive an email when new articles are posted on . There is a need to look past dopaminergic therapy and target inflammation for disease modification. Chronic ...

A new study frames TREM-1 as an upstream innate immune amplifier, mapping out a new therapeutic target for sepsis, arthritis, and neurodegeneration.

Though it's not yet clear whether the links are biological, research is beginning to uncover promising connections.