This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive ...

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the ...

PHILADELPHIA ­— Cancer cells’ quick moves may make them skilled escape artists. Some cancer cells appear to wriggle away from immune cells trying to gobble them up. These evasive maneuvers — caught on ...

A key pressure-sensing protein involved in intestinal movement and inflammation regulation has been identified. Researchers from Harvard Medical School (MA, USA) and the Icahn School of Medicine at ...